Glucagon

Glucagon is a hormone produced by the pancreas that raises blood sugar levels, primarily by signaling the liver to release stored glucose. It works opposite to insulin, which lowers blood sugar. While GLP-1 medications suppress glucagon secretion to help control blood sugar, some newer investigational medications ("triple agonists") intentionally add glucagon receptor activity alongside GLP-1 and GIP, since glucagon can also increase energy expenditure and fat oxidation — a different mechanism being explored to enhance weight loss.