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Using GLP-1s

Lipohypertrophy

A rubbery lump of thickened fatty tissue under the skin caused by repeated injections in the same spot.

By the glp1.how editorial teamReviewed

Lipohypertrophy is a rubbery lump of thickened fatty tissue that can form under the skin when injections are given repeatedly at the same site. Injecting into one of these lumps can make medication absorption less predictable.

It is generally prevented by rotating injection sites rather than reusing the same spot.

International injection-technique recommendations describe lipohypertrophy as a frequent complication that distorts absorption, and advise not injecting into these lumps and rotating sites correctly to prevent them (Mayo Clinic Proceedings (external link)).

lipohypertrophyinjectionside-effectsglossary

Revision history

Updated 1 time since Jul 18, 2026 · show changes
  1. v2

    Body revised

  2. v1

    Change tracking began

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