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Progestogen

A hormone — natural progesterone or a synthetic progestin — given alongside estrogen in menopausal hormone therapy to protect the lining of the uterus.

By the glp1.how editorial teamReviewed

A progestogen is a hormone that acts on the body like progesterone. The term covers both natural progesterone and synthetic versions known as progestins.

In menopausal hormone therapy, a progestogen is often given together with estrogen for people who have a uterus. Estrogen on its own can cause the uterine lining to build up, which raises the risk of uterine cancer, and the progestogen counteracts that effect to protect the lining. The specific type and dose are decided with a prescriber. See the guide on HRT for women and GLP-1 medications. Source: National Cancer Institute (external link).

hormonesmenopause

Revision history

Updated 1 time since Sep 2, 2026 · show changes
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    Body revised

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Related terms

  • Menopausal hormone therapy (MHT) · Estrogen, usually combined with a progestogen (when the uterus is present), used to relieve menopausal symptoms such as hot flashes and to protect bone. Often just called 'HRT.' It is associated with less visceral fat but is not a weight-loss treatment.

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