Anhedonia

Anhedonia is a diminished ability to experience pleasure, including from previously enjoyable activities like eating. Because GLP-1 medications act on brain reward and dopamine pathways to reduce hedonic (pleasure-driven) eating, some patients report a broader blunting of enjoyment beyond food. This effect is an active area of research, and anyone experiencing persistent low mood, loss of interest, or reduced enjoyment of life should discuss it with their prescriber — it can be a sign to reassess dose or treatment.