Compounded semaglutide is semaglutide prepared by a licensed compounding pharmacy, often during periods of brand-name drug shortages, rather than manufactured and sold as an FDA-approved product like Ozempic or Wegovy. Compounded versions are not FDA-approved, are not held to the same manufacturing and quality standards, and their safety and dosing accuracy has been a subject of regulatory scrutiny — worth discussing with a prescriber before use.