Gastroparesis

Gastroparesis literally means "stomach paralysis" and refers to delayed gastric emptying. GLP-1 medications intentionally slow gastric emptying to a degree, which contributes to fullness and can cause nausea, bloating, or reflux. In rare cases, this effect can become severe enough to be diagnosed as clinical gastroparesis, which may require dose adjustment or discontinuation — worth discussing with a provider if symptoms are persistent or severe.