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Zofran

Brand name for ondansetron, an anti-nausea medication sometimes prescribed alongside GLP-1 medications to manage nausea side effects.

Updated Sep 26, 2026

Zofran is the brand name for ondansetron, an anti-nausea (antiemetic) medication originally developed for chemotherapy-related nausea. Its FDA label covers preventing nausea and vomiting from chemotherapy, radiation therapy and surgery (Zofran prescribing information (external link)). It's sometimes prescribed off-label alongside GLP-1 medications to help manage nausea, particularly during dose titration when GI side effects tend to be most pronounced.

It eases the symptom but doesn't change what the GLP-1 itself is doing. GLP-1 nausea comes partly from slowed gastric emptying and partly from the drug acting on GLP-1 receptors in the brain (Borner et al., British Journal of Pharmacology, 2021 (external link)). If nausea is significantly affecting your daily life or your ability to eat, it's worth raising with your prescriber.

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